4.5· 806 reviews

Vegan Daily Cleanse Papaya Enzymes

A plant-sourced enzyme blend that helps your body break down proteins, fats, and carbs from everyday meals.

  • Vegan
  • Non-GMO
  • Soy-Free
  • Gluten-Free
  • Made in USA
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Supplement Facts

Supplement Facts

Serving Size: 2 chewable tablets

Servings Per Container: 45

Nutrient Amount Per Serving % DV*
Total Carbohydrate <1g <1%
Papain (from Papaya) 35TU/mg 200mg *
Papaya fruit 10mg *
Bromelain (from pineapple) 1.6 GDU/mg 10mg *
Plant Enzyme Blend (supplying amylase, protease, lipase) 10mg *

* Percent Daily Values are based on a 2,000 calorie diet.

** Daily Value not established.

Other Ingredients: Xylitol, vegetable stearic acid, natural tropical flavors, cellulose, citric acid, turmeric root (for color), silica, vegetable magnesium stearate and high purity steviol glycosides.

How to Use
Chew 2 tablets after a heavy meal to support digestion.
Research

The studies below reference peer-reviewed research on the key active ingredients in this product. These are ingredient-level studies.

Papain (papaya enzyme)

  • Muss et al., 2013 · Neuro Endocrinology Letters

    Double-blind, placebo-controlled RCT; small sample (N≈13); 40 days

    Participants who received a standardized papaya preparation (Caricol®) showed statistically significant improvements in constipation and bloating scores compared to those who received placebo; the study authors noted that small sample size limited statistical power for some outcomes including heartburn.

  • Somanah et al., 2012 · Preventive Medicine

    Randomized controlled trial; sample size not reported in abstract; 14 weeks; fermented papaya preparation (6g/day)

    Participants who received a fermented papaya preparation daily showed significantly reduced C-reactive protein levels (P=0.018) and improved LDL/HDL cholesterol ratio (P=0.042) compared to baseline; the preparation studied was a fermented form and results may not directly translate to unfermented raw papain.

Bromelain (pineapple enzyme)

  • Castell et al., 1997 · American Journal of Physiology

    Double-blind RCT; n=19 healthy men; multi-dose phase over 48 hours

    Participants who received oral bromelain showed measurable intact enzyme in plasma with a half-life of 6–9 hours, demonstrating that bromelain is absorbed across the gastrointestinal epithelium and retains enzymatic activity in circulation following oral dosing.

  • Pereira et al., 2023 · Clinical Nutrition ESPEN

    Systematic review of RCTs; 7 eligible trials included; 1–16 week durations; dosages 99.9–1,200 mg/day

    A systematic review of randomized controlled trials found that participants who received bromelain supplementation showed reductions in inflammatory markers including IL-6, TNF-α, and CRP in most included studies, with gastrointestinal adverse effects reported as well-tolerated across the reviewed trials.

  • Delgarm et al., 2025 · Scientific Reports

    Randomized, triple-blind, placebo-controlled trial; n=70; 8 weeks; participants with mild-to-moderate ulcerative colitis

    Participants with mild-to-moderate ulcerative colitis who received 400mg/day of bromelain showed significantly larger reductions in disease activity scores compared to those who received placebo (P < 0.001); quality-of-life measures did not differ significantly between groups in this population.

Plant Enzyme Blend (amylase, protease, lipase)

  • Majeed et al., 2018 · Journal of Medicinal Food

    Randomized, double-blind, placebo-controlled trial; n=40; 60 days; participants with functional dyspepsia

    Participants with functional dyspepsia who received a multienzyme complex containing amylase, protease, and lipase (DigeZyme®) showed statistically significant improvements across all measured efficacy outcomes compared to those who received placebo (P ≤ 0.04), with no adverse events reported; enzyme blend composition may differ from the blend in this product.

  • Ullah et al., 2023 · Biomedicine & Pharmacotherapy

    Randomized, double-blind, placebo-controlled trial; n=120; 2 months; participants with functional dyspepsia

    Participants with functional dyspepsia who received a multi-enzyme supplement containing amylase, protease, and lipase showed statistically significant improvements in quality-of-life scores, pain severity, and sleep quality compared to those who received placebo, with no side effects reported.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How it works

Every ingredient, chosen with intention.

Here's what's in this bottle - and why each ingredient earned its place in the formula.

  1. Papain

    Papain from ripe Carica papaya fruit

    A plant-sourced digestive enzyme that helps break down proteins into smaller peptides and amino acids as food moves through the stomach and small intestine.

    Why we chose it

    Sourced directly from papaya fruit at a meaningful 200mg dose, not a synthetic substitute, so it delivers the full enzymatic activity the plant naturally produces.

  2. Bromelain

    Bromelain from pineapple stem

    A proteolytic enzyme from pineapple that works alongside papain to help break down proteins across a wider range of digestive conditions.

    Why we chose it

    Bromelain is active across a different pH range than papain, so pairing them gives the formula broader enzymatic coverage throughout the digestive tract, not just in one compartment.

  3. Whole Papaya Fruit

    Whole Papaya Fruit Carica papaya

    The whole fruit matrix adds naturally occurring papaya compounds beyond the concentrated enzyme extract, reflecting what you'd encounter in the real fruit.

    Why we chose it

    Rather than relying solely on an isolated enzyme, Yuve includes whole papaya fruit so the formula carries the fuller plant profile, the way nature packages it, not just one extracted compound.

  4. Plant Enzyme Blend

    Plant Enzyme Blend amylase, protease, and lipase from plant sources

    Three additional enzymes that together help the body break down carbohydrates, proteins, and fats found in a typical mixed meal.

    Why we chose it

    Most meals are a mix of carbs, fats, and protein, a formula focused only on one macronutrient type leaves work undone. This broad-spectrum blend supports digestion across all three.

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Pairs well with

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Questions, answered

What customers often ask.

How long before I notice a difference?
Many people notice a shift in how they feel after heavier meals within the first week of daily use. For more consistent digestive comfort, studies on papain and the plant enzyme blend suggest two to four weeks of regular use tends to show the clearest difference. Results vary by diet and individual gut chemistry.
Should I take these with food or on an empty stomach?
With or right after meals. Digestive enzymes help your body break down what you’ve just eaten, they need food present to do that work. Taking them on an empty stomach leaves them without anything to act on.
Can I take these alongside your Probiotic Gummies?
Yes, they’re complementary, not redundant. These tablets support the breakdown of food as it moves through the stomach and small intestine. The probiotic gummies work further down, supporting the gut’s microbial environment. Most people who take both do so daily without issue.
Is this safe during pregnancy or while breastfeeding?
Please consult your healthcare provider before adding any supplement during pregnancy or breastfeeding. This formula uses ripe papaya extract, not unripe papaya, which carries different considerations, but supplement decisions during pregnancy are always best made alongside your doctor.
Are these sweetened with sugar? What do they taste like?
No sugar. These are sweetened with xylitol and steviol glycosides (from stevia), making them suitable for those watching sugar intake. They’re chewable tablets with a mild tropical flavor, light enough that most people find them easy to take right after a meal.
Why does this combine papain AND bromelain, isn’t one enough?
Papain and bromelain both help break down proteins, but each is most active at slightly different points along the digestive tract. Pairing them gives broader enzymatic coverage from the stomach through the small intestine. The plant enzyme blend, amylase, protease, and lipase, extends that to carbohydrates and fats as well.

What customers say

Results, backed by reviews.

  • 5 stars: 523 (65%)
  • 4 stars: 173 (21%)
  • 3 stars: 67 (8%)
  • 2 stars: 38 (5%)
  • 1 star: 5 (1%)
b
booksandboots3
UPDATE: six weeks in

I bought this after realizing my after-lunch slump was often more about feeling stuffed than actually being tired. I work from home and had gotten into a terrible habit of grabbing whatever was quick, then sitting back down at my desk. Day 1 through 5: no obvious difference. I almost forgot about the bottle. Week 2: mornings were a little more regular and I didnt have that brick-in-my-stomach feeling after every lunch. Week 3: I went out for a heavy birthday dinner and expected the usual uncomfortable evening, but I felt surprisingly normal. That was the moment I started paying attention. It is now week 6 and the change has held even though my meals are far from perfect. This isnt some loud instant effect, it has just made digestion feel less like a daily project. My husband asked why I keep moving the bottle next to the toaster and I said 'because thats the only place I remember anything before 8am.' Fair. I have not changed the dose or added anything else. Really happy I stuck with it!!

N
Nora Feldman
Steady improvement

I have used the Daily Cleanse consistently for approximately five weeks. My goal was not anything dramatic, just a gentler and more regular morning routine. During the first ten days I noticed very little, aside from no stomach discomfort, which I appreciated. In week two things became more consistent. By week four I could eat my usual breakfast, work through the morning, and not feel weighed down. The capsules are easy to swallow and there is no strange taste. I am giving four stars because the serving adds another bottle to an already crowded counter, but the product itself has been reliable.

M
MASON D.
Back to feeling normal

I travel for work and restaurant meals can leave me feeling uncomfortably full. Started keeping this beside my coffee so I would actually remember it. Not an overnight difference, but by the second week I wasnt thinking about my digestion all afternoon. That is a win for me!!

C
Camille R.
not for me

three weeks... nothing changed. bottle is fine but im not buying it again

r
river_stone8
Took a little time

week 1 i didnt notice much. By the end of week 3 my mornings felt more predictable and heavy meals were not sitting with me forever

H
HARVEY C.
good morning habit

i take these with breakfast and feel lighter after lunch. simple and gentle

E
Elaine
No fuss

Easy.

M
MARTIN Q.
Finally found a gentle one

I bought this after a long stretch of trying powders, teas, and capsules that either did absolutely nothing or made me plan my whole morning around staying near home. I was honestly suspicious of another bottle with cheerful promises on the label. For the first several days I didnt notice much. Around the end of week two, I realized I had stopped complaining about feeling stuffed after ordinary meals. That was the first clue. By week three my morning routine was simply more consistent. Not urgent, not uncomfortable, just normal. That matters a LOT when your commute starts before seven and there is no room for surprises. I take it with breakfast and plenty of water. On a recent trip I skipped two days because the bottle was buried in my suitcase, and I could tell the difference by the second evening. My sister asked whether it was a cleanse that makes you miserable and I said 'no, it is almost boring,' which is meant as a compliment. No weird cramping for me, no racing to find a restroom, and no elaborate schedule. It just fits into real life. I cant speak for everybody, but for me the slow and steady effect is why I reordered.

S
Simone Avery
A calm change

I have used these for a little over five weeks, usually with my first meal. The difference has been subtle but consistent: less of that overfull feeling after lunch and a much easier morning routine. I appreciate that they have not felt harsh or urgent. I travel for work and was nervous about taking them on hotel days, but there was no drama at all. My husband asked why I was packing the bottle again and I told him 'because this is the first one I actually remember to take.'

D
Deirdre N.
took a while

week 1 nothing. week 2 maybe a little lighter after dinner. week 3 was when i noticed my mornings were more predictable... decent but slower than i expected tbh

p
papertrail_6
Gentle but noticeable

Nothing dramatic, just more regular mornings and no crampy feeling. Exactly what I wanted.

C
CONRAD E.
easy routine

i take these with breakfast and dont feel as heavy after lunch anymore

M
Mae
Works

Works!!

M
Mallory Pierce
not much for me

month 1 nothing. kept going bc I already had the bottle. month 2 maybe a little more regular but honestly not enough that I can say it made a real difference. the tablets were fine and didnt bother my stomach, thats about all I noticed. I track meals and water pretty closely so I was hoping adding this would make the mornings more predictable. It didnt. Some days were easier and some were exactly the same as before. Finished the full supply and wont reorder rn

k
keats_73
gentle but took time

I expected something dramatic in a few days, but this is more subtle. Around week three I noticed I was more regular and not getting that heavy after-meal feeling as often. Gentle enough that I can actually stay consistent with it.

R
ROLAND B.
easy routine

two with breakfast and i dont feel weighed down after lunch. simple

J
June
Yep

Works.

N
Nadine Flores
Finally a routine I can stick with

I bought these during a stretch when every lunch seemed to sit with me until bedtime. I was skeptical because I have a cabinet full of half-used supplements and most of them either felt too harsh or were impossible to remember. For the first week I noticed basically nothing. During week two I realized I was not reaching for tea after dinner just to feel settled. By week four the difference was obvious: breakfast felt lighter, my schedule was more predictable, and I wasnt thinking about digestion all afternoon. The best part is that it has been gentle. No sudden urgency, no weird cramping, no elaborate timing. I leave the bottle beside the coffee maker and take it with breakfast. My partner asked why I had stopped complaining after takeout and I laughed because I hadnt even noticed that change myself. I still eat normally and I dont expect a supplement to erase every questionable meal, but this has quietly become one of the few things I reorder before the bottle is empty. UPDATE: two months in and STILL part of my morning routine!!

b
beckett_reads
not much for me

month 1 nothing. month 2 maybe a little more regular but honestly not enough to keep paying for it. I finished the bottle and thats it

M
MILES P.
Easy routine

I take it after breakfast. feels gentle and I dont get that heavy stuffed feeling by lunch anymore

T
Tara
Yep

Works!!!

T
Thomas Bell
Six weeks and still impressed

I started this after a stretch of travel when every meal seemed to be airport food, restaurant food, or something eaten too late at night. My normal breakfast routine disappeared and so did any sense of regularity. A friend had a bottle of these and said 'just give it a few weeks before you decide.' I rolled my eyes because I have a cabinet full of products that promised a better routine and mostly delivered clutter. Still, I began taking one each morning with water. The first week was unremarkable. During week two I noticed that lunch no longer left me wanting to loosen my waistband and lie down. Week three was when it clicked: I had gone several days without thinking about digestion at all, which is honestly the best outcome. After I got home I kept taking them with breakfast, even on weekends. Six weeks in, my mornings are more predictable and heavy meals dont seem to hang around FOREVER. There has been no harsh rush, cramping, or strange artificial feeling. It is simply gentler than the cleanse products I tried years ago. My wife asked why this bottle was actually on the counter instead of buried in the supplement drawer, and I told her 'because I remember to take the things that make a difference.' She laughed and ordered one for herself. UPDATE: we are both still using it, and I already bought a backup before the first bottle ran out 🙂

F
Felicia R.
Not much happened

month 1 nothing. month 2 maybe a slightly easier morning once or twice but not enough to justify another bottle. i took it with breakfast like the label says and didnt skip days. The capsules themselves were fine, no weird taste, no stomach upset, but I bought this for regularity and that part stayed inconsistent. Some days felt lighter after lunch, other days exactly the same as before. I even kept a note in my phone bc I thought maybe I was overlooking a slow change... nope. By the last week I was mostly annoyed that I had spent two months waiting. Giving three stars only because it was gentle and easy to swallow. Results were barely there for me

e
emmett_56
Skeptic converted

tbh I assumed this was another bottle that would sit behind the coffee until it expired. My sister left it at my apartment and told me to at least try a full month, so fine. Week one, nothing worth reporting. Week two, I noticed I wasnt feeling quite as weighed down after breakfast. By week four my morning routine felt more predictable and I was reaching for the bottle without her texts. The capsules dont have a harsh smell and they have been easy on my stomach, which matters bc other enzyme products made me queasy. I am not suddenly eating perfectly or pretending one supplement does everything. I just feel lighter after meals and more regular than I did before. ordered my own bottle yesterday, so yes she gets to say she told me so lol

L
Louis K.
ok WOW

I bought these on a whim after another heavy dinner left me feeling like a balloon. Didnt expect much because digestive supplements have been hit or miss for me. By the second week I realized I was no longer planning my evenings around that overfull feeling. I still eat normally, including the occasional ridiculous restaurant meal, but the next few hours are much easier. HUGE difference for such a small change in my breakfast routine!!

P
PATRICIA G.
Noticeably lighter after meals

I have used this product consistently for approximately five weeks. Digestion after lunch feels more comfortable, and my usual afternoon heaviness is less noticeable. No dramatic claims from me, just a steady improvement that has made it worth continuing.

M
Maribel S.
Gentle after breakfast

I take these with breakfast. feels gentle and I dont get that heavy post-meal feeling anymore

R
Renee
It works

Works.

w
wade koester

we love this product.

H
Harold T.
Still waiting

ive taken this with breakfast for almost a month. first week felt lighter after lunch, since then its been pretty inconsistent. some mornings are easier and some are exactly the same. bottle is easy to use but tbh i expected more by now